Science

Clinical trials. Research findings. Data. Metrics. Numbers.

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Study: Malaria death toll nearly twice the official count, kills many adults

Flickr, ACJ1

A new global estimate of malaria deaths by researchers in Seattle has revealed the death toll is much greater than most experts had thought — and is not, as had been universally assumed, mostly a killer of children.

The study found more than 1.2 million people died from malaria in 2010, nearly twice the official estimate put out by the World Health Organization, and more than a third of the deaths were in adults.

The common wisdom has been that 99 percent of malaria deaths are in young children because adults develop immunity.

“This radically changes the picture,” said Dr. Christopher Murray, lead author of the study and director of the University of Washington’s Institute for Health Metrics and Evaluation (IHME).

Continue reading

Gates Fdn’s Tweets reveal passive, insular global health community

The Bill & Melinda Gates Foundation is hosting a number of events today in anticipation of the opening of the philanthropy’s new public visitor center. Social media, and media in general, will play a big role in it.

If they use Twitter or Facebook to tell people about it, chances are the story will look like this:

Marc Smith, Connected Action

A snapshot of the Gates Foundation's Twitterverse

That’s a Twitter Map (here’s a more readable but huge link) made by Marc Smith, a sociologist who studies online communities, founder of the Social Media Research Foundation and former chief of Microsoft Research’s community technologies group.

The map, he says, indicates a fairly insular and uncommunicative bunch of folks.

“It’s mostly just an echoing of the Gates Foundation,” said Smith. “There’s not a lot of response, or engagement. Basically, it looks like people preaching to the choir.”

Continue reading

Associated Press: Gates calls for more money for ag research

The Associated Press

A farmer checks his hybrid maize crop in Catandica, Mozambique.

KIRKLAND, Wash. — Bill Gates says high tech approaches to agriculture are an important tool for fighting hunger.

Gates released his fourth annual letter Tuesday, detailing the work of the Bill & Melinda Gates Foundation, the world’s largest charitable foundation. It made grants totaling $2.6 billion in 2010, spending heavily to improve health and the fight hunger in poor nations.

Gates lamented that more money isn’t spent on agriculture research and noted that of the $3 billion spent annually on work on the seven most important crops, only 10 percent focuses on problems in poor countries.

He says given the central role food plays in human welfare and national stability, it’s shocking, short-sighted and potentially dangerous how little money is spent on agricultural research.

From Gates’ letter:

“The world faces a clear choice. If we invest relatively modest amounts, many more poor farmers will be able to feed their families. If we don’t, one in seven people will continue living needlessly on the edge of starvation. My annual letter this year is an argument for making the choice to keep on helping extremely poor people build self-sufficiency.”

On the Web:

To publish and perish? Scientists create scary new flu bug

Flickr, Y

The U.S. government is opposing full publication by scientists of their methods used to create a mutant form of bird influenza based on the fear it could be used by terrorists to launch a deadly pandemic.

As reasonable as this may sound, many see the government’s position as unworkable and inappropriate.

As Nature magazine and GlobalPost report, some say the researchers should not be allowed to publish their findings because such knowledge would be dangerous in the wrong hands.

On Friday, a compromise position was floated — a three-month hold on publishing while the scientific community figures out how to balance the fundamental need for free and open exchange of ideas with the desire to minimize the potential risk of misuse of scientific information to do harm.

The mutant strain of flu variant H5N1 was created as part of ongoing research to prepare for a major pandemic. As Nature reports:

The mutant strains were not born out of a reckless desire to push the boundaries of high-risk science, but to gain a better understanding of the potential for avian H5N1 to mutate into a form that can spread easily in humans through coughing or sneezing.

That seems prudent enough, but some outside the scientific community are raising the alarm over plans to publish the findings in scientific journals. As The Independent reported:

A deadly strain of bird flu with the potential to infect and kill millions of people has been created in a laboratory by European scientists – who now want to publish full details of how they did it.

The discovery has prompted fears within the US Government that the knowledge will fall into the hands of terrorists wanting to use it as a bio-weapon of mass destruction.

There is reason for caution and precautions have already being taken, beginning with the standard laboratory containment measures. But this is also perhaps evidence why we need to better educate people — apparently including many folks in positions of great power — on statistics and relative risk. Continue reading

PATH acquires drug company to speed fight on neglected diseases

Seattle-based PATH announced today that it is acquiring the non-profit drug company OneWorld Health.

OneWorld Health, which will continue to operate from its headquarters in San Francisco, was created in 2000 as the first non-profit pharmaceutical company and has been focused from the beginning on creating drugs and vaccines for use in poor countries.

“I don’t think we could have considered trying to partner with a for-profit drug company,” said Hugh Chang, head of special projects at PATH who will act as interim chief of drug development for the PATH-OneWorld Health merger. “That would have been a misalignment in terms of our missions.”

PATH, launched in the late 1970s in Seattle initially focused on women’s health issues, has grown into one of the largest players in the global health arena — due largely to its key role administering and carrying out many well-funded projects sponsored by the Bill & Melinda Gates Foundation.

Known for its talent at bringing together public and private partners in innovative ways to solve health problems in poor countries, this is the first time PATH will have a direct role in developing drugs.

In the past, PATH has had to spend a lot of time and effort working to convince drug makers to join in the fight against neglected diseases. Now it is a drug maker. Continue reading

Gates Foundation’s latest global health gizmo grant

Sorry, I know alliteration indicates some kind of mental pathology (as does the love of puns) but I couldn’t resist that headline.

Flickr, MikeBlogs

Star Trek tricorder

At least I didn’t report this news like my former employer, the Seattle PI, as Canadians, Gates Foundation want a real tricorder. For the six people in the world who don’t know what a ‘tricorder’ is, it’s a futuristic medical device used by the cranky medical officer Bones in the TV show Star Trek to diagnose maladies on the final frontier.

Oh, and the actual news? The Bill & Melinda Gates Foundation, working in partnership with a Canadian version of the foundation’s Grand Challenges program, has awarded $32 million to 22 research teams to develop new, inexpensive “point-of-care” diagnostic devices.

It’s fairly easy for the media to do stories about fighting disease in poor countries (though we don’t do it enough, as compared to celebrity news or politics). What’s often neglected is the lack of an ability to even know what disease it is you are fighting in the developing world. Is the fever due to malaria or flu? Does this person with HIV also have TB or not?

The need for inexpensive and more reliable disease diagnosis in poor countries is massive.

“New and improved diagnostics to use at the point-of-care can help health workers around the world save countless lives,” said Chris Wilson, Director of Global Health Discovery at the Bill & Melinda Gates Foundation. “Our hope is that these bold ideas lead to affordable, easy-to-use tools that can rapidly diagnose diseases, trigger timelier treatment and thereby reduce death, disability and transmission of infections in resource-poor communities.”

The Gates Foundation’s Grand Challenges program was launched to fund high-risk innovative scientific and engineering research aimed at solving problems of disease and poverty in poor countries. Grand Challenges Canada is an independent organization, inspired by the Gates program but funded by the Canadian government to do pretty much the same kind of thing.

Of the 22 research projects awarded by the two organizations, only 10 of the 12 groups funded by the Gates Foundation website appeared to be listed as of this writing. The Canadians also only appear to list a portion of their grantees rather than all of them. I’ve asked for one link listing all 22 but haven’t seen it yet.

Here are three grant recipients highlighted by the Gates Foundation:

  • Seventh Sense Biosystems, a company located in Cambridge MA, is developing TAP—a painless, low-cost blood collection device which aims to allow easy, push-button sampling of blood. This simple collection process would reduce training requirements and enable diagnostics closer to the point-of-need.
  • David Beebe and researchers at the University of Wisconsin are developing a sample purification system that seeks to better filter and concentrate biomarkers from patient samples. This system will be designed for use in impoverished settings.
  • Axel Scherer of the California Institute of Technology, along with collaborators at Dartmouth College, will develop a prototype quantitative PCR (qPCR) amplification/detection component module—a low cost, easy-to-use technology that can rapidly detect a wide range of diseases.

Other news stories based on this announcement:

Boston Globe Gates Foundation awards grant to (beantown biotech)

AFP Gates, Canadians offer $32 million for research

Using satellite ‘light mapping’ to track disease outbreaks

This is kinda cool, as a possible means to track human migration and perhaps infectious disease risk — satellite tracking of light emissions.

Princeton University

Lights in Niger

The disease outbreak idea here seems like a bit of a stretch, I have to say.

What these researchers are tracking are population levels based on light output. From the population density, they infer the risk of disease outbreaks. I would think a more reliable diagnosis will still be best obtained by health workers on the ground. But who knows? Read for yourself.

From Princteon University:

Princeton University-led researchers report in the journal Science Dec. 9 that nighttime-lights imagery presents a new tool for pinpointing disease hotspots in developing nations by revealing the population boom that typically coincides with seasonal epidemics. In urban areas with migratory populations, the images can indicate where people are clustering by capturing the expansion and increasing brightness of lighted areas. The researchers found the technique accurately indicates fluctuations in population density — and thus the risk of epidemic — that can elude current methods of monitoring outbreaks.

World mostly punts on climate change

The New York Times’ John Broder called it a “modest accomplishment” while Inter Press’ Stephen Leahy described it as “yet another failure.”

Both are news stories reporting on the conclusion of the week of intense climate change talks in Durban, South Africa — technically known as the UN Frameworks Convention on Climate Change.

Given the predictions by many that nothing much was going to happen, some say the agreement to continue the talks represents some kind of progress. Others not so much. As the NYTimes reports:

The conclusion of the meeting was marked by exhaustion and explosions of temper, and the result was muddled and unsatisfying to many. Observers and delegates said that the actions taken at the meeting, while sufficient to keep the negotiating process alive, would not have a significant impact on climate change.

“While governments avoided disaster in Durban, they by no means responded adequately to the mounting threat of climate change,” said Alden Meyer, director of policy at the Union of Concerned Scientists. “The decisions adopted here fall well short of what is needed.”

This is the same UN gathering that, in 1997, came up with the Kyoto Protocol, an agreement aimed at reducing greenhouse gas emissions that has had some problems and has been due to expire soon. Among the agreements reached in Durban, the Kyoto treaty was extended until 2017 or so.

Some of the key (mostly still unresolved) sticking points at the climate change meeting were about how to best assign responsibilities between rich and poor nations and how to support the growth of “green” economies and policies in the rapidly growing developing world.

The world’s biggest polluters — the U.S., China and India — were widely viewed in Durban as presenting the biggest obstacles to reaching consensus.

In a nutshell, the international community has largely punted on climate change, kicking the can down the road to be resolved later. Meanwhile, many say parts of Africa and other regions in the tropics will continue to suffer from altered weather patterns, rainfall and agriculture caused by climate change.

As The Guardian reported:

The deal did little to meet the needs of poor people already fighting climate change, and risked blurring important distinctions between the responsibilities of developed and developing countries…. The science of climate change tells us that, to avoid catastrophic levels of warming – and the droughts and floods that would inevitably follow – global emissions, which are rising at record speed, must peak within the next five years. The Durban deal’s provisions for action within this time period are vague.

Here are a few more reports out of Durban worth a look:

Atlantic How the world failed to address climate change, again

WashPost Five things to know about Durban climate pact

Reuters New Climate Deal Struck, Modest Gains

Alertnet Climate talks agree to keep disagreeing

SciDev Climate deal leaves questions on funding, tech transfer