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UW and British scientists explore how to spread genetically modified mosquitoes to fight malaria

Flickr, Gustavo

Over the last few years, scientists have explored a number of different approaches to genetically modify mosquitoes in order to make them unable to pass on the malaria parasite, or other causes of human illness.

The Bill & Melinda Gates Foundation is a big supporter of this strategy, having donated nearly $40 million in research funding to various scientific endeavors. One of the primary challenges, besides accomplishing the genetic modification in the lab, is in getting the protective changes to spread in the wild when the bugs breed.

In this week’s scientific journal Nature, a team of researchers at Imperial College London and the University of Washington report the first-ever successful “proof-of-principle” demonstration in which such genetic modifications get passed on by modifying a few individuals who then breed them into the population at large.

Reuters quotes the lead scientist at Imperial College:

“This is an exciting technological development, one which I hope will pave the way for solutions to many global health problems,” said Andrea Crisanti of Imperial’s life sciences department, who led the study.

The UW scientists involved in the study included Summer B. Thyme, Hui Li, Umut Y. Ulge, Blake T. Hovde, David Baker and Raymond J. Monnat Jr.

New skeeter bugs malaria control campaign

CDC

Anopheles gambiae

One of the big news stories in the malaria world recently is the discovery, announced last week in the journal Science, of a previously unknown type of mosquito that some reports said could threaten malaria control efforts in Africa.

Here’s the problem: Most malaria control efforts in Africa — bednets, spraying — are aimed at preventing mosquitoes from biting humans indoors at night. This newly discovered mosquito, dubbed “Goundry” (after the community in Burkina Faso where it was identified), appears to operate outdoors. The news reports:

After reading a number of these stories that cited the scientists who made this discovery warning that this new skeeter could undermine the massive — and apparently fairly successful — ongoing effort to reduce malaria deaths and disease in Africa, I decided to get a second opinion.

I asked Stefan Kappe, a malaria expert at Seattle Biomed, for his thoughts on this. Kappe and his colleagues are working on a number of fronts to combat malaria, including testing a genetically engineered malaria parasite for use as a vaccine.

Seattle Biomed

Stefan Kappe

“If it turns out that this mosquito is a significant vector for human malaria, the whole malaria control strategy will fail,” said Kappe. But that, he says, remains a big “if” because it’s quite possible this particular sub-type is one of those that doesn’t bite humans.

The species Anopheles gambiae, of which the Goundry bug is a subtype, does transmit malaria and Goundry has been shown to carry the malaria parasite.

But it’s worth considering that, in the mosquito world, there are some 3,500 known species of mosquito — most which don’t carry malaria and most of which aren’t attracted to biting humans for their blood meal.

“What they did not show is that this mosquito will actually bite and transmit malaria to humans,” said Kappe. “It might seem like a trivial question but it’s not really.”