Seth Berkley

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The obscure bug that set off Bill Gates, awakening a geeky giant

Tom Paulson

Nelson Zambrana cradles his child sick from rotavirus in Nicaraguan hospital

It kills anywhere from a quarter-million to half-a-million kids every year and is one of the world’s leading causes of child mortality.

But it wasn’t too long ago hardly anybody had even heard of it.

Rotavirus — the killer bug that set off Bill Gates and gave direction to his philanthropy.

“No matter where we looked in the world, about 40 percent of all kids under 5 years old in hospitals for severe and life-threatening diarrhea had rotavirus,” said John Wecker, head of Seattle-based PATH’s vaccine access and delivery program. PATH has a long history advocating for a rotavirus vaccine.

“We’d go into these countries where huge numbers of kids were dying from diarrhea and they’d say ‘Rota what?” Wecker said. “We don’t have that here. Nobody had ever heard of it.”

Today, an international group that represents the Bill & Melinda Gates Foundation‘s single largest philanthropic project aimed at expanding children’s vaccinations announced it was launching a major new global jab against rotavirus and another big killer of young children, pneumococcal disease. The campaign focuses on Africa, where these two infectious diseases are rampant.

“The death toll of rotavirus and pneumococcal infections in Africa is particularly devastating, and this is where these vaccines will make the most significant impact, not only in lives saved, but also in terms of healthy lives lived,” said Seth Berkley, CEO of this group known as GAVI, the Global Alliance for Vaccines and Immunization.

It’s a major milestone for GAVI, for a number of reasons, but in a way just another big step forward in a decade of significant progress for this alliance created to expand access to childhood immunizations in poor countries.

Since it was launched, hundreds of millions of children have been vaccinated and an estimated 5 million deaths prevented.

That’s more deaths averted than has so far been credited to the much-larger Global Fund for Fighting AIDS, TB and Malaria — or any other single project in the global health arena, for that matter. Continue reading

Did something that matters happen at the UN global health summit?

Tom Paulson

The media covering the media covering President Obama speaking at the UN

The big global health meeting at the United Nations has come and gone I still can’t quite tell if anything actually happened.

Maybe that’s normal, when it comes to how things get done at the UN.

After all, the Obama Administration has said if the UN were to recognize Palestine as a state, it would be “merely symbolic.” And yet they’re still fighting like hell to keep it from happening.

I came to New York to cover a meeting called the UN High-Level Meeting on Non-Communicable Diseases, which concluded yesterday. This was billed as a historic moment in global health, only the second time the UN has held such a meeting. The last one, in 2001, launched the Global Fund to Fight AIDS, TB and Malaria — a massive, if imperfect, effort that has saved millions of lives.

The aim of this week’s special session on global health at the UN General Assembly meeting is potentially even more significant than it may sound.

On the surface, it was a call to expand the already strained global health agenda to include non-infectious killers like cancer, diabetes and heart disease — the NCDs (or non-communicable diseases). That’s a big deal because it adds a lot to the agenda, given that chronic diseases kill more people (about 36 million per year) than AIDS, TB and malaria combined.

But it may be even bigger than that.

If you dig a little deeper here, this is the big — mostly unspoken — question: Is this move to get chronic disease on the agenda actually a move away from the standard disease-oriented approach to global health — and toward a more “systems” approach? Continue reading

Global vaccine alliance appoints AIDS vaccine champ as new CEO

IAVI

Seth Berkley

The Global Alliance for Vaccines and Immunization, GAVI, has selected Seth Berkley to take over as CEO of the 10-year-old initiative aimed at expanding access to children’s vaccines worldwide.

Berkley, long one of the leading advocates of the search for an AIDS vaccine, inherits both an operation that has been one of the most successful, life-saving efforts ever undertaken in global health and a massive funding shortfall.

His predecessor, Julian Lob-Levyt, announced his resignation after the board learned of the funding shortfall and had concerns about his financial management (and, to some extent, his management style as well. A bit autocratic). Lob-Levyt left GAVI to join a small development management firm called DAI.

The vaccination initiative that Berkley now takes on is the largest single project ever funded by the Gates Foundation, which launched it in 2000. Here’s a story of GAVI’s early days, which I wrote based on a trip to Africa while at the Seattle Post Intelligencer. Continue reading